Endocrine Abstracts

Similarly as in autoimmune Addison’s disease (AAD), diagnosed in about 80% of primary adrenal insufficiency, idiopathic isolated secondary adrenal insufficiency (ISAI) seems to have an autoimmune origin.Within the last 35 years we have registered in our Department 325 patients with ISAI (F/M ratio 10.9) aged 17–87 years. In comparison, we have in our registry 241 patients with AAD, collected within over 40 years. The diagnosis of ISAI was based...

The course of Graves’ disease is associated with the inflow of lymphocytes to the thyroid gland and dysregulation of the immune system characterized by reaction to thyroid antigens (peroxidase, thyroglobulin, TSH receptors and Na+/I− symporter).The aim of this study was to estimate sodium iodine symporter (NIS) and thyroid peroxidase (TPO) expression in thyrocytes which release cytokines INF-γ and IL-4 from young pat...

It is believed that differentiated thyroid tumors (DTC) metastasize via different pathways: papillary carcinoma (PTC) usually via lymphatic spread whereas follicular cancers (FTC) mainly hematogenously. However, the mechanism/s contributing to these tumors invasion is not fully understood.We examined the expression of lymphatic endothelial markers: Podoplanin (type-1 transmembrane mucin-like glycoprotein) and Prox1 (Prospero homeobox protein 1) in the PT...

Pendred syndrome is an autosomal recessive disorder with congenital-sensorineural deafness and goiter due to mutations in SLC26A4, that encodes a transmembrane protein, Pendrin. In thyrocytes, Pendrin is proposed to act at the apical pole to transport intracellular iodide into the follicular lumen.A Galician Pendred compound heterozygous patient was studied; a c.297delT in exon 3 and a new splicing-mutation c.416-1G<A were found, introducing p...